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Suppose that an investigator wants to estimate an association between a continuous exposure variable and an outcome, adjusting for a set of confounders. If the exposure variable suffers classical measurement error, in which the measured exposures are distributed with independent error around the true exposure, then an estimate of the covariate-adjusted exposure-outcome association may be biased. R

https://www.lupop.lu.se/article/reducing-bias-due-exposure-measurement-error-using-disease-risk-scores - 2025-12-19

In aspiring to be discerning epidemiologists, we must learn to think critically about the fundamental concepts in our field and be able to understand and apply many of the novel methods being developed today. We must also find effective ways to teach both basic and advanced topics in epidemiology to graduate students, in a manner that goes beyond simple provision of knowledge. Read the paper at ht

https://www.lupop.lu.se/article/simulation-tool-teaching-and-learning-epidemiologic-methods - 2025-12-19

Factorial Mendelian randomization is the use of genetic variants to answer questions about interactions. Although the approach has been used in applied investigations, little methodological advice is available on how to design or perform a factorial Mendelian randomization analysis. Read the paper at https://academic.oup.com/ije/article/49/4/1147/5542600?rss=1

https://www.lupop.lu.se/article/factorial-mendelian-randomization-using-genetic-variants-assess-interactions - 2025-12-19

Unmeasured confounding can bias the relationship between exposure and outcome. Sensitivity analyses generate bias-adjusted measures but these are not much used; this may change with the availability of the E-value (for evidence for causality in observational studies), appealing for its ease of calculation. Read the paper at https://academic.oup.com/ije/article/49/5/1509/5913108

https://www.lupop.lu.se/article/bias-factor-maximum-bias-and-e-value-insight-and-extended-applications - 2025-12-19

We illustrate the method and some potential choices using data from England for men diagnosed with melanoma. Various marginal measures are presented and compared. Read the paper at https://academic.oup.com/ije/article/49/5/1614/5896134

https://www.lupop.lu.se/article/reference-adjusted-and-standardized-all-cause-and-crude-probabilities-alternative-net-survival - 2025-12-19

The PhD position is linked to the research project The long reach of the neighborhood: Health, education and earnings in Landskrona, Sweden, 1904-2015, funded by Handelsbankens forskningsstiftelser. The PhD student will work in this project in collaboration with other project members and will be affiliated with the Centre for Economic Demography at LUSEM (CED, www.ed.lu.se). Read more and apply he

https://www.lupop.lu.se/article/phd-position-economic-history-neighborhood-effects-over-life-course - 2025-12-19

Find out how GDPR will affect you and your research! More information, including programme, here.

https://www.lupop.lu.se/article/gdpr-event - 2025-12-19

This paper describes the multiform, wave-missing and two-method designs, including their benefits, their impact on bias and power, and other factors that must be taken into consideration when implementing them in an epidemiological study design. Read the paper at https://academic.oup.com/ije/article/49/5/1702/5827680

https://www.lupop.lu.se/article/reflection-modern-methods-planned-missing-data-designs-epidemiological-research - 2025-12-19

This study extends TCAL by disentangling causes of death contributions. The strength of the approach is that it allows identification of mortality differences in cohorts with members still alive, as well as identification of which ages and causes of death contribute to mortality differentials between populations. Read the paper at https://academic.oup.com/ije/article/49/5/1712/5721433

https://www.lupop.lu.se/article/reflection-modern-methods-cause-death-decomposition-cohort-survival-comparisons - 2025-12-19

The most common form of childhood cancer is acute lymphoblastic leukaemia (ALL). Together with Karolinska Institutet, SciLifeLab and the University of Cambridge, researchers at Lund University have conducted the largest ever analysis of ALL at protein level by studying activity in more than 8,000 genes and proteins. The results of the study show a deviant folding of the DNA strand which in turn af

https://www.medicine.lu.se/article/first-large-scale-study-proteins-patients-all - 2025-12-19

Being able to take care of one’s hygiene, cook food and cope independently in the home are examples of feeling in control of one’s life. But how easy is it for an elderly person with a spinal cord injury to feel actively in control of their life in the home? Lizette Norin, occupational therapist and researcher, has written a thesis on the importance of accessibility in the home. First published: 2

https://www.medicine.lu.se/article/accessibility-home-key-person-spinal-cord-injury - 2025-12-19

Applications for the nomination of academic innovation projects and medium-cost equipment to the Mats Paulsson Foundation for Research, Innovation and Community Development First published: 2019-05-06In the text below, the Mats Paulsson Foundation for Research, Innovation and Community Development describes the purpose of the announcement and how applications are to be structured.The Foundation ha

https://www.medicine.lu.se/article/nominate-projects-mats-paulsson-foundation - 2025-12-19

In recent years, it has become increasingly clear to researchers that the protein galectin-3 is involved in inflammatory diseases in the brain. A study led by researchers at Lund University in Sweden now shows the de facto key role played by the protein in Alzheimer’s disease. When the researchers shut off the gene that produces this protein in mice, the amount of Alzheimer’s plaque and the inflam

https://www.medicine.lu.se/article/researchers-block-protein-plays-key-role-alzheimers-disease - 2025-12-19

A European consortium, led from Lund University, is to receive SEK 50 million from the EU for research which is to develop our understanding of the functional mechanisms of the brain. The research project, called INTUITIVE, is one of the Innovative Training Networks within the framework of Horizon 2020. The aim of the project is to develop user interfaces based on touch that feel more intuitive th

https://www.medicine.lu.se/article/additional-sek-50-million-research-brains-mechanisms - 2025-12-19

Researcher Louise Brunkwall at Lund University explains how three risk factors are involved in obesity. Louise Brunkwall recently defended her PhD thesis Obesity; with a focus on diet quality and gut microbiota. In this clip, she discusses how the three known risk factors for obesity interplay to determine your risk:  

https://www.medicine.lu.se/article/watch-three-risk-factors-behind-obesity - 2025-12-19

For over 20 years, a team of researchers at Lund University has worked on developing a drug against preeclampsia – a serious disorder which annually affects around 9 million pregnant women worldwide and is one of the main causes of death in both mothers and unborn babies. Now the researchers have published a study in the journal Scientific Reports that opens up opportunities for further research t

https://www.medicine.lu.se/article/clinical-trials-beginning-possible-preeclampsia-treatment - 2025-12-19

Researchers from Lund University, together with the Roche pharmaceutical company, have used a method to develop a new blood marker capable of detecting whether or not a person has Alzheimer’s disease. If the method is approved for clinical use, the researchers hope eventually to see it used as a diagnostic tool in primary healthcare. This autumn, they will start a trial in primary healthcare to te

https://www.medicine.lu.se/article/new-blood-test-detecting-alzheimers-disease - 2025-12-19

Researchers at Lund University in Sweden have investigated the link between osteoarthritis and mortality in an epidemiological study. It was shown that the risk of dying from cardiovascular disease was higher for people with osteoarthritis than for the rest of the population. Read full length article on the Lund University international webpage 

https://www.medicine.lu.se/article/osteoarthritis-linked-higher-risk-dying-cardiovascular-disease - 2025-12-19

More than half of our genome consists of transposons, DNA sequences that are reminiscent of ancient, extinct viruses. Transposons are normally silenced by a process known as DNA methylation, but their activation can lead to serious diseases. Very little is known about transposons but researchers in an international collaboration project have now succeeded for the first time in studying what happen

https://www.medicine.lu.se/article/study-sheds-light-darker-parts-our-genetic-heritage - 2025-12-19

An extensive study has confirmed that the risk of developing coeliac disease is connected to the amount of gluten children consume. The new study is observational and therefore does not prove causation; however, it is the most comprehensive of its kind to date. The results are presented in the prestigious journal JAMA. In total, 6 600 children at increased risk of developing coeliac disease were f

https://www.medicine.lu.se/article/association-between-coeliac-disease-risk-and-gluten-intake-confirmed - 2025-12-19